Cystic fibrosis (CF) newborn screening (NBS) has been performed throughout the United States since 2010. CF newborn screening has led to early diagnosis in most affected infants and improves health outcomes. A summary of the evaluation of the first decade of universal NBS is attached for care providers and public health professionals. The educational tool was created by Ann & Robert H. Lurie Children's Hospital of Chicago, Stanley Manne Children's Research Institute, and the Cystic Fibrosis Foundation.